Failure of surfactant therapy

• Type of lung injury

• Degree of the lung pathology at the time of supplementation

• Complexity of the disease, e.g. multiorgan failure (MOF)

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The efficacy of the treatment is connected with the primitive lung injury and possibility to recover from the pathology. Negative results may also be attributed both to delay in the treatment and multiorgan failure, cases in which the lung represents only a minor factor.