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• Oxygen improvement

• Improvement in compliance

• More uniform lung inflation

• Decrease of inflammation and implementation of defence mechanisms from bacterial and viral (?) infections on the lung

Surfactant: major acute effects

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An antinfective effect, principally towards group B Streptococcus, has been observed both in vitro and in vivo. An antiviral effect has also been described. Such effects are most likely connected to SP-A.

Sherman MP, Campbell LA, Merritt TA, Long WA, Gunkel JH, Curstedt T, Robertson B. Effect of different surfactant on pulmonary group B streptococcal infection in premature rabbits. J Pediatr 1994; 125:939-947

Herting E, Jarstrand C, Rasool O, Curstedt T, Sun B, Robertson B. Pediatr Res 1994

Le Vine AM, Bruno MD, Huelsman KM, Ross GF, Whitsett JA, Korfhagen T. J. Immunol 1997

Herting E, Gefeller O, Land M, van Sonderen L, Harms K, Robertson B and Members of the Collaborative European Multicenter Study Group. Pediatrics 2000