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Early stage

Late stage

Characteristics

Low dose

Large dose

Therapeutic effects

Proposed therapy based on lung injury stage at the time of treatment

• Homogeneous lung injury

• No severe reduction of compliance

• Presence of oedema and protein in alveoli

• Reduced lung compliance

• Improvement of gas exchange

• Allows the lungs to heal

• Prevents progressive lung disfunction

• Faster healing of lungs

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Precocious treatment, particularly in the presence of still homogeneous lung pathology and with normal compliance, allows the use of reduced doses and prevents progressive deterioration of the lung

Late intervention and when compliance is reduced, are situations requiring higher doses to balance the inhibitory effect of the proteins present in the alveolar oedema. Repeated surfactant supplementation may be necessary to improve the lung pathology, often obtaining only improvement in gas exchange without curing the lung pathology completely.