Diapositiva 59 di 71
Note:
Acute respiratory distress syndrome (ARDS) is a lung pathology induced by diverse injuries, including trauma, sepsis, liquid aspiration, inhaled gases, radiation pneumonitis and many others.
Despite the introduction of new treatments, the mortality from ARDS also in paediatric age remains high (about 40%).
The pathophysiological features of the acute lung injury in ARDS are similar to those observed in neonatal hyaline membrane disease, leading to speculation that ARDS might involve a surfactant deficiency.
Surfactant supplementation has been suggested but the treatment is unpredictable. Poor response may be due to inhibition of administered surfactant by plasma components filling the alveolar space, severity of lung injury, time of surfactant application and inadequate dose.
Auten RL, Notter RH, Kending JW, Davis JM, Shapiro DL. Pediatrics 1991
Marraro G, Foresti B, Casiraghi G, Riva A. In Bevilacqua G et al. Eds “Surfactant in clinical practice”. Harwood Acad Publish 1992
Khammash H, Pearlman M, Wojtulewicz J, Dunn M. Pediatrics 1993
Marraro G. J Anaesth Clin Pharmacol 1995
Marraro G, Casiraghi G, Riva A, Galbiati A. Riv Ital Pediatr (IJP) 1995
Spragg RG. Biol Neonate 1998
Lopez-Herce J, de Lucas N, Carrillo A, Bustinza A, Moral R. Arch Dis Child 1999
Taeusch HW. Biol Neonate 2000
Greenough A.. Eur J Pediatr 2000
